Figure 3

The ulcer index (UI) following HCl/ethanol treatment. (a) Adult, gender-matched littermate pairs of Wt and Tg mice were orally administered HCl/ethanol, killed 6, 12, 18 or 24 h after gavage and their stomachs were scored for cumulative length of gastric erosions (UI). Values for each pair of littermates (each connected by thin dashed line) and mean values at each time point for Wt mice (stippled boxes connected by thick dotted line) and Tg mice (filled boxes connected by thick solid line) are presented. Number and gender of experimental animals were as follows. For 6 h, n=9 pairs (5 male pairs, 4 female pairs); for 12 h, n=12 pairs (6 male pairs, 6 female pairs); for 18 h, n=11 pairs (6 male pairs, 5 female pairs); for 24 h, n=10 pairs (5 male pairs, 5 female pairs). ^*P<0.05. (b) Representative macroscopic appearance of gastric mucosa at each time point (a group of female littermates). (c) Representative macroscopic appearance of gastric mucosa at 6 h examined at high magnification (female Wt mice).