Figure 2

Histological changes, pathologic scores, and serum amylase levels in pancreas with and without CDE diet-induced acute pancreatitis. (a, b, e, f, i, j, m, n, q, r) Saline-treated mice. (c, d, g, h, k, l, o, p, s, t) Cerulein-treated mice. (b, d, f, h, j, l, n, p, r, t) Higher magnification of areas indicated in (a, c, e, g, i, k, m, o, q, s). (u) Pathologic scores calculated based on five parameters: edema (E), hemorrhage (H), infiltrates (I), vacuolization (V), necrosis (N) of acinar cells. (v) Column graph of the pathologic scores shown as mean±s.d. (error bar). (w) Serum amylase levels. Black arrows indicate respective inflammatory changes. Scale bar: 50 μm. *P<0.05. NS: no significance.