Figure 5

Trypsin activity and LC3-II expression. (a) Trypsin activity in cerulein-induced and CDE-diet-induced acute pancreatitis. Trypsin activity coincided with protein expression level of Prss1. (b) LC3-II/LC3-I ratio in cerulein-induced and CDE diet-induced acute pancreatitis. LC3-II levels were inversely related to Spink3 levels when treated with cerulein, suggesting the function of Spink3 as an inhibitor of autophagy.