Figure 2

Two-way unsupervised hierarchical clustering of laser capture microdissected (LCM) cancer stroma and extrapolated value. Relative intensity values of 75 different signaling proteins obtained by reverse-phase protein microarray were used. (a) LCM-procured cancer stroma (CS-LCM); (b) extrapolated value (EV) (EV=WhT intensity value × % cancer epithelium). Red indicates a high relative level of protein activation or expression, black for median value and green indicates low relative level of protein activation or expression.