Figure 4 | Laboratory Investigation

Figure 4

From: Oxidative stress-associated rise of hepatic protein glycation increases inflammatory liver injury in uncoupling protein-2 deficient mice

Figure 4

Plasma AST (a) and ALT activities (b), and histomorphometric analysis of necrosis (c) in UCP2+/+ (n=21) and UCP2−/− animals (n=21). Animals were injected with either saline (sham; n=14), G/L (720 mg/kg/10 μg/kg BW i.p.) (G/L; n=14) or recombinant RAGE (10 μg i.p.; rRAGE+G/L; n=14) at 12 h before G/L challenge. In all animals, analysis was carried out 6 h after G/L exposure. Note the high AST and ALT activities in G/L-exposed UCP2+/+, but in particular in UCP2−/− mice and the significant attenuation of injury after rRAGE pretreatment in the UCP2−/− mice. Values are given as means±s.e.m.; ANOVA, post hoc pairwise comparison tests: #P<0.05 vs UCP2+/+; *P<0.05 vs sham; §P<0.05 vs G/L.

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