Table 1 Morphological alterations in group T20d
From: Overexpression of SERPIN B3 promotes epithelial proliferation and lung fibrosis in mice
Control—PBS (20 mice) | Treatment—BLM (20 mice) | |||||
|---|---|---|---|---|---|---|
Parameters | WT | TG | WT | TG | ||
Mean±s.d. | Mean±s.d. | P | Mean±s.d. | Mean±s.d. | P | |
Architectural remodeling (%) | 2.2±2.3 | 1.0±0.8 | 0.21 | 23.1±15.3 | 16.8±9.7 | 0.26 |
Fibrosis extension (%) | 0.0 | 0.0 | — | 8.3±5.6 | 25.5±15.7 | 0.01, 0.003a |
Inflammation (%) | 7.5±4.6 | 6.8±7.8 | 0.39 | 16.4±7.8 | 7.2±4.6 | 0.01, 0.05b |
Apoptotic index (%) | 0.3±0.7 | 0.4±0.7 | 0.54 | 1.5±0.9 | 0.9±0.8 | 0.18 |
Proliferative index (%) | 0.7±0.7 | 2.6±2.4 | 0.07 | 3.1±1.4 | 6.5±2.9 | 0.007 |
(%) | (%) | P | (%) | (%) | P | |
Bronchiolization grading >2 | 0% | 12% | 0.44 | 90% | 90% | — |
Dysplasia (presence) | 0% | 12% | 0.44 | 60% | 80% | 0.63 |
Neoplastic transformation (presence) | 0% | 0% | — | 10% | 40% | 0.30 |
