Figure 1 | Laboratory Investigation

Figure 1

From: Phospholipase Cɛ has a crucial role in ultraviolet B-induced neutrophil-associated skin inflammation by regulating the expression of CXCL1/KC

Figure 1

Histological findings of the time course of neutrophil infiltration in the epidermis of PLCɛ+/+ and PLCɛ−/− mice irradiated with 1 kJ/m2 of UVB. The shaved dorsal skins of PLCɛ+/+ and PLCɛ−/− mice were irradiated with a single dose of UVB at 1 kJ/m2 (n=10 for each PLCɛ background, 5 male mice and 5 female mice). Skin specimens were prepared at 0, 12, 18, 24, 48, and 168 h after irradiation, and were stained with H&E. Representative photographs of skin sections from PLCɛ+/+ (+/+) and PLCɛ−/− (−/−) mice are shown. Insets in (b) and (c) show a blood vessel containing neutrophils and neutrophil infiltration in the stroma of the dermis, respectively. Neutrophil microabscesses are surrounded by dotted lines in (d) and (e). Bar, 100 μm.

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