Figure 1
From: Wnt activation is implicated in glioblastoma radioresistance
Xenograft model of U87MG and U373MG. (a) Schedule of radiation therapy in intracranial xenograft models generated with U87MG (2 × 105 per mouse), U373MG (1 × 105 per mouse), and GBM578 (5 × 104 per mouse; median survival of 28, 21, and 56 days, respectively). (b) Survival analysis of U87MG (left panel) and U373MG (right panel) xenografts with either mock (c) or 10 Gy whole-brain ionizing radiation (IR). (c) Soft agar clonogenic assay of parental cell lines (left panel; square=U87MG, circle=U373MG), U87MG ex-vivo cell lines (middle panel; open square=U87-C, closed square=U87-IR), and U373MG ex-vivo cell lines (right panel; open circle=U373-C, closed circle=U373-IR). Abbreviations: IC=intracranial, C=control (mock IR). (d) Limiting dilution assay (LDA) of ex-vivo cells from GBM578 xenografts treated with mock (578-C) or 10 Gy IR (578-IR). LDA clonogenic index is measured as the inverse of the x-intercept; higher number indicates higher colony-forming efficiency. 578-IR have higher baseline colony-forming efficiency than 578-C (P<0.05).
