Figure 5
From: Wnt activation is implicated in glioblastoma radioresistance
Radiosensitization by inhibiting Wnt signaling. (a) Sox2 and active β-catenin (ABC) dual staining of U373-C and U373-IR, with or without 16 h treatment with Wnt pathway inhibitor XAV939 (5 μM). There was a significant difference between the groups (P<0.05 Student's t-test). (b) Corresponding soft agar clonogenic assay of U373-C (squares) and U373-IR (circles) with (closed symbols) or without (open symbols) the addition of XAV939 (5 μM). (c) Soft agar clonogenic assay of U373-C (squares) and U373-IR (circles) transfected with non-targeting siRNA (open symbols) or with β-catenin siRNA (closed symbols).
