Table 1 Partial list of Wnt signaling genes with significant expression level changes identified by microarray analysis

From: Wnt activation is implicated in glioblastoma radioresistance

Symbol

Gene

Description

P-value

Fold-change

PRICKLE4

NM_013397

Prickle homolog 4 (Drosophila) (PRICKLE4)

0.018

3.66

WISP1

NM_080838

WNT1-inducible signaling pathway protein 1 (WISP1), transcript variant 2

0.046

3.64

FZD1

NM_003505

Frizzled homolog 1 (Drosophila) (FZD1)

0.014

2.62

APC

NM_001127511

Adenomatous polyposis coli (APC), transcript variant 1

0.013

1.98

CITED1

NM_004143

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1

0.014

1.92

LEF1

NM_016269

Lymphoid enhancer-binding factor 1 (LEF1), transcript variant 1

0.031

1.77

TCF4

NM_003199

Transcription factor 4 (TCF4), transcript variant 2

0.030

1.70

PPARD

NM_006238

Peroxisome proliferator-activated receptor delta

0.038

1.68

CTNNBIP1

NM_020248

Catenin, beta interacting protein 1

0.016

1.67

NLK

NM_016231

Nemo-like kinase

0.019

1.56

CHD8

NM_020920

Chromodomain helicase DNA binding protein 8

0.046

1.40

RUVBL1

NM_003707

RuvB-like 1 (E. coli)

0.003

−1.29

SMAD4

NM_005359

SMAD family member 4 (SMAD4)

0.001

−1.46

PPP2R5C

NM_178587

Protein phosphatase 2, regulatory subunit B′, gamma isoform

0.018

−1.67

WNT9B

NM_003396

Wingless-type MMTV integration site family, member 9B

0.038

−1.89

AXIN2

NM_004655

Axin 2 (AXIN2)

0.006

−1.90

  1. Positive and negative fold-change values indicate upregulation and downregulation in U373-IR compared with U373-C, respectively.