Figure 1 | Laboratory Investigation

Figure 1

From: Reversal of liver fibrosis by the antagonism of endocannabinoid CB1 receptor in a rat model of CCl4-induced advanced cirrhosis

Figure 1

Hepatic fibrosis. (a–d) Representative images of H&E-stained liver sections ( × 40) from healthy rats (CT), pre-ascitic cirrhotic rats (CHBasal) and rats receiving the vehicle (CHVehicle) or 10 mg/kg/day of the cannabinoid type 1-antagonist Rimonabant (CHRimonabant) for 2 additional weeks. Representative images of Sirius Red stained liver section are inserted in the upper right corner of each panel. (e) Quantification of the fibrotic area expressed as percent of the total area. (f) Hepatic hydroxyproline tissue content. Data are expressed as mean±s.e.

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