Figure 6

Hepatic expression of pro- and anti-inflammatory molecules implicated in the fibrogenic process. Hepatic gene expression of (a) tumor necrosis factor-α (TNF-α), (b) monocyte chemotactic protein-1 (MCP-1), (c) interleukin-10 (IL-10) and (d) suppressor of cytokine signaling-3 (SOCS3) in healthy rats (CT), in pre-ascitic cirrhotic rats (CH^Basal) and in rats receiving the vehicle (CH^Vehicle) or 10 mg/kg/day of the cannabinoid type 1-antagonist Rimonabant (CH^Rimonabant) for 2 additional weeks. Values were determined by real-time PCR and expressed as fold induction over control healthy rats. Data are expressed as mean±s.e.