Figure 4
Prevention by DDTC of CCl4-induced (a) ALT and (b) AST elevation and (c) histological modifications. H&E staining was performed on liver slices from eight mice per group. ALT and AST data are mean±s.e.m. for 18–28 mice (3 h time-point) or 9 mice (24 h time-point) per group. *Significantly different from control mice (P<0.05). #Significantly different from CCl4-treated mice (P<0.05). Representative pictures (magnification × 250) of the liver of control mice or mice treated for 3 h with 1.5 ml CCl4, with or without pretreatment with DDTC, as well as inlays of centrilobular hepatocytes at higher magnification ( × 500) are shown. CV, centrilobular vein.
