Figure 9
Scheme showing lipid peroxidation-dependent and -independent early toxicity induced by CCl4. Mitochondrial alterations including mtDNA damage and respiratory chain complex IV inhibition are prevented by both DDTC and antioxidants whereas mild cytolysis, swelling of centrilobular hepatocytes and increase of defense/stress-related enzymes are prevented only by DDTC. This suggests that mitochondrial alterations seen 3 h after the treatment result from lipid peroxidation induced by CCl4 metabolic activation. Other modifications seem to be directly linked to the formation of the free radicals CCl3. and CCl3OO. and do not depend on lipid peroxidation.
