Table 3 Effects of antioxidants on early (3 h) CCl4-induced modifications
Control | CCl4 | DHEA | DHEA+CCl4 | TROLOX | TROLOX+CCl4 | |
---|---|---|---|---|---|---|
ALT (IU/l) | 67.4±7.7 | 223.4±46.2a | 89.5±22.3 | 151.5±22.0 | 99.3±20.9 | 314.8±41.7a |
AST (IU/l) | 129.7±24.3 | 473.3±91.4a | 177.0±26.7 | 256.4±35.5 | 133.5±20.0 | 534.4±116.7a |
TBARS (nmol/mg protein) | 0.11±0.01 | 0.15±0.01a | 0.10±0.01 | 0.09±0.01b | 0.12±0.02 | 0.09±0.01b |
Complex IV (nmol/min/mg protein) | 20.6±2.1 | 2.0±0.7a | 16.8±0.9 | 13.0±0.8b | 28.0±6.0 | 18.6±5.4b |
mtDNA/nDNA (fold-change) | 1.00±0.11 | 0.78±0.07a | 0.89±0.11 | 1.01±0.11b | 1.03±0.09 | 0.85±0.09 |
Long/short mtDNA fragments (fold-change) | 1.00±0.05 | 0.55±0.08a | 0.94±0.06 | 1.01±0.07b | 0.98±0.06 | 0.99±0.03b |
CY2E1/S6 (fold-change) | 1.00±0.09 | 0.42±0.04a | 0.93±0.03 | 0.45±0.04a | 0.78±0.07 | 0.40±0.03a |
HO-1/S6 (fold-change) | 1.0±0.2 | 18.0±3.6a | 0.9±0.1 | 20.3±4.5a | 1.0±0.1 | 30.4±3.5a |
Hsp70/S6 (fold-change) | 1.0±0.1 | 82.9±8.1a | 1.5±0.1 | 114.8±33.6a | 1.2±0.2 | 145.1±16.7a,b |
MnSOD/S6 (fold-change) | 1.00±0.05 | 0.81±0.03a | 0.91±0.09 | 0.82±0.06 | 0.96±0.13 | 0.86±0.07 |