Figure 3 | Laboratory Investigation

Figure 3

From: Aged vervet monkeys developing transthyretin amyloidosis with the human disease-causing Ile122 allele: a valid pathological model of the human disease

Figure 3

TTR amino acid sequence alignment for the 15 primate species, and human TTR mutations. The shaded area indicates conserved sequences in the primates. *Conserved amino acid residues in all 15 primates; †sequence data examined in this study; ‡sequence data cited from GenBank; ND, not determined. §Mutation-causing amyloid PN type; mutation-causing amyloid C type; ∥mutation developing LM amyloid deposits causing CNS symptoms; **mutation developing V-type amyloid deposits causing visual disturbance; and ††with shading: nonamyloidogenic mutation. Del, deletion of amino acid residue.

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