Figure 5 | Laboratory Investigation

Figure 5

From: Aged vervet monkeys developing transthyretin amyloidosis with the human disease-causing Ile122 allele: a valid pathological model of the human disease

Figure 5

TTR gene expression and serum TTR concentrations in cynomolgus monkeys and vervet monkeys. (a) TTR gene expression in cynomolgus monkeys in the liver (n=5) and in vervet monkeys in various tissues including the liver. (b, c) Serum TTR concentrations measured by means of nephelometry. (b) Comparison of serum TTR concentrations in 15 cynomolgus monkeys (male: n=6, female: n=9) and 13 vervet monkeys (male: n=4, female: n=9). *P<0.0001. (c) Serum TTR concentrations of vervet monkeys with (EF <50%, n=4) and without (EF >50%, n=9) cardiac dysfunction. Error bars show the s.d.

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