Table 2 QLα12LacZ+/Cre+ mice score higher for glomerular injury

From: Gα12 activation in podocytes leads to cumulative changes in glomerular collagen expression, proteinuria and glomerulosclerosis

Injury

Podocytes

GBM

 

FP EFF

FP IRREG

MicrovilIL

KNOBS

DCs

Genotype

C

++

C

++

C

++

C

++

C

++

Scores by age (months)

 <12

0

0.33

0.75

1

0.5

0.33

0.25

0.67

0

0

 12–18

1

0.6

1.3

1

1

1

1.67

1.4

0.33

1

 18–24

0

1.5

0.33

1.8

0.66

1.25

1

2

0

1.2

Injury

Endothelium

 

Subend dep

Swelling

MES matrix

MES cells

Genotype

C

++

C

++

C

++

C

++

Scores by age (months)

 <12

0

0

0

0.33

0.75

1

0.5

0.67

 12–18

0

0.6

0

0.6

1

1.8

1

1.2

 18–24

0

0.88

0

1

1.3

2.6

1.7

2.4

  1. C, control mice; ++, QLα12LacZ+/Nphs2−Cre+ mice; FP, foot process;
  2. EFF, effacement; IRREG, irregularity;
  3. DC, double contours; MES, mesangial.
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