Figure 6
From: Metal-free imidazolium salts inhibit the growth of hepatocellular carcinoma in a mouse model
IBN-9 reduced cell proliferation in HCC tissue. Immunohistochemistry with the Ki67 antibody revealed an active cell proliferation in the tumor tissue (a). Treatment with IBN-9 (1.5 g/l for 21 days) resulted in a 66% (P<0.001) reduction in the number of proliferating cells in the tumor (b). Similarly, the elevated expression of survivin (c) and Cdk4 (e) as seen in the untreated tumor tissues were significantly reduced in tumor tissues treated with IBN-9 (1.5 g/l for 21 days), with (d) being survivin and (f) being Cdk4.
