Figure 2

Changes in net tissue-type plasminogen activator (tPA) activity following morphine administration. (a) Nonlinear regression best-fit second-order coefficients from amidolytic assays were performed on lysates of the cortex, sub-cortical regions and cerebellum of wildtype (WT) mice at 2 h after intraperitoneal administration of saline or morphine. (b) Fold-change in tPA activity in morphine vs saline administered groups (n=5 per treatment group; data represents mean±s.e.m.). Data derived from panel a.