Figure 3

Table summarizing the anticipated characteristics of cells/tissues/individuals harboring mitochondria having higher or lower economy in regard to cellular-tissue oxidant generation and individual propensity for weight gain under positive or negative energy balance. An asterisk (*) indicates relative to higher economy; however, under conditions of persistent positive energy balance, even cells/tissues/individuals with decreased (lower) mitochondrial economy will exhibit the same features as those with higher economy due to chronic stress. It is predicted that these features will be related to specific mtDNA sequences, or shared mutations between mtDNA haplotypes (representing mtDNA haplogroups).