Figure 5 | Laboratory Investigation

Figure 5

From: Inhibition of active autophagy induces apoptosis and increases chemosensitivity in cholangiocarcinoma

Figure 5Figure 5

Inhibition of autophagy suppressed established tumor growth in nude mice. (a) Nude mice bearing established QBC939 tumors were given injections of either vehicle control DMSO or wortmannin (2 mg/kg). After 10 days, tumors were excised. (b) Tumors were weighted at the time of animal killing. Autophagy-related genes ATG5 (c) and beclin1 (d) mRNA expression were detected by real-time PCR. (e) Established tumors were treated with AdSi-beclin or AdSi-blank for 2 weeks. (f) Tumors were weighted at the time of killing. (g) Tumor slices were tested by beclin 1 and CK19 staining after ad-virus treatment. *P<0.05; **P<0.01 (n=5).

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