Figure 10 | Laboratory Investigation

Figure 10

From: Liver inflammation in a mouse model of Th1 hepatitis despite the absence of invariant NKT cells or the Th1 chemokine receptors CXCR3 and CCR5

Figure 10

Expression levels of specific cytokines are differentially influenced by TGF-β1, CD1d/iNKT cells, CXCR3, and CCR5. Cytokines were analyzed in day 11 samples by Luminex, and results are displayed as in the legend to Figure 8. (a) Some cytokines (G-CSF, IL-6, IL-10) are strongly overexpressed in plasma from Tgfb1−/− mice; expression levels are largely independent of functional Cd1d, Cxcr3, or Ccr5 genes. (b) These cytokines show highest expression when both Tgfb1 and Cxcr3 are knocked out, but levels revert when Ccr5 is additionally knocked out. (c) Expression levels of some cytokines (GM-CSF, IL-15) are unaffected in Tgfb1−/− mice. (d) Expression levels of some cytokines (LIX, IL-9) are reduced in Tgfb1−/− mice.

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