Figure 2

Histological liver damage in Tgfb1−/− mice is independent of CD1d/iNKT cells, CXCR3, and CCR5. Low power micrographs of H&E-stained livers from mice of the following genotypes: (a) Tgfb1+; (b) Tgfb1−/−; (c) Cd1d−/−Tgfb1−/−; (d) Cxcr3−/−Tgfb1−/−; (e) Ccr5−/−Tgfb1−/−; (f) Cxcr3−/−Ccr5−/−Tgfb1−/−. Obvious necrosis of the liver is observed in Tgfb1−/− mice, independent of the presence or absence of CD1d/iNKT cells, CXCR3, CCR5, or CXCR3/CCR5.