Figure 2 | Laboratory Investigation

Figure 2

From: Liver inflammation in a mouse model of Th1 hepatitis despite the absence of invariant NKT cells or the Th1 chemokine receptors CXCR3 and CCR5

Figure 2

Histological liver damage in Tgfb1−/− mice is independent of CD1d/iNKT cells, CXCR3, and CCR5. Low power micrographs of H&E-stained livers from mice of the following genotypes: (a) Tgfb1+; (b) Tgfb1−/−; (c) Cd1d−/−Tgfb1−/−; (d) Cxcr3−/−Tgfb1−/−; (e) Ccr5−/−Tgfb1−/−; (f) Cxcr3−/−Ccr5−/−Tgfb1−/−. Obvious necrosis of the liver is observed in Tgfb1−/− mice, independent of the presence or absence of CD1d/iNKT cells, CXCR3, CCR5, or CXCR3/CCR5.

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