Figure 2 | Laboratory Investigation

Figure 2

From: Dissecting the phenotypes of Plk1 inhibition in cancer cells using novel kinase inhibitory chemical CBB2001

Figure 2

CBB2001 effectively induces mitotic arrest of cancer cells with mitotic ‘polo’ phenotypes. (a), (b) HeLa cells were treated with CBB2001 as well as reported Plk1 inhibitory chemicals ON01910 and LFM-A13, for 20 h. They were analyzed by microscopy and flow cytometry. Bar=40 μm. (c) The percentage induction of the mitotic ‘polo’ cells for experiments in (a) or (b) was used to calculate the EC50 of CBB2001 or ON01910, respectively.

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