Table 1 Ability of acute exposure to cromolyn to inhibit features of PCA or PSA responses in vivo or mast cell degranulation in vitro in rats and mice
From: Evidence questioning cromolyn’s effectiveness and selectivity as a ‘mast cell stabilizer’ in mice
Previous reports | This report | |||||
|---|---|---|---|---|---|---|
Rat | Mouse | Rat | Mouse | |||
In vivo | PCA | Evans blue extravasation | No30 | Yes (10 mg/kg) | No (10 or 100 mg/kg) | |
Ear swelling | No (10 or 100 mg/kg) | |||||
Leukocyte infiltration | No (10 or 100 mg/kg) | |||||
PSA | Histamine release | Yes (10 mg/kg) | No (10 or 100 mg/kg) | |||
Temperature decrease | No (10 or 100 mg/kg) | |||||
mMCP-1 release | Yes (only at 100 mg/kg) | |||||
In vitro | PMCs | Yes (10 or 100 μM) | No (1–100 μM) | |||
BMCMCs | No39 | No (1–100 μM) | ||||
Mucosal mast cells | No14 | |||||
