Table 2 Univariate and multivariate analysis for 10-year melanoma-specific mortality

From: In situ measurement of miR-205 in malignant melanoma tissue supports its role as a tumor suppressor microRNA

 

Univariate analysis

Multivariate analysis

 

HR

95% CI

P-value

HR

95% CI

P-value

n=105

Discovery cohort

Breslow

 <2.0 mm

1

  

1

  

 >2.0 mm

1.931

1.003–3.721

0.0491

1.828

0.922–3.626

0.0843

Age, years

1.019

0.997–1.041

0.0917

1.022

0.997–1.047

0.0796

Sex

 Male

1

  

1

  

 Female

0.907

0.495–1.662

0.752

1.085

0.575–2.047

0.802

Stage at diagnosis

 Localized

1

  

1

  

 Regional

2.596

1.062–6.157

0.0363

2.561

1.045–6.299

0.0398

 Distant

3.205

1.242–8.268

0.016

4.169

1.574–11.039

0.0041

miR-205 expression

 Low

1

  

1

  

 High

0.534

0.288–0.990

0.0463

0.4

0.207–0.773

0.0064

n=192

Validation cohort

Breslow

 <2.0 mm

1

  

1

  

 >2.0 mm

3.014

1.489–6.101

0.002

2.603

1.186–5.714

0.0171

Age, years

1.022

1.000–1.045

0.052

1.031

1.005–1.057

0.0169

Sex

 Male

1

  

1

  

 Female

0.53

0.262–1.069

0.076

0.557

0.263–1.177

0.125

Stage at diagnosis

 Localized

1

  

1

  

 Regional

2.686

1.316–5.484

0.0066

2.189

1.017–4.713

0.0452

 Distant

7.726

1.80–33.10

0.0059

28.238

5.52–144.42

<0.001

miR-205 expression

 Low

1

  

1

  

 High

0.506

0.266–0.965

0.0386

0.511

0.262–0.997

0.0489

  1. Abbreviations: CI, confidence interval; HR, hazard ratio.
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