Figure 3 | Laboratory Investigation

Figure 3

From: Steatosis does not impair liver regeneration after partial hepatectomy

Figure 3

mRNA expression of fatty acid transport proteins in liver tissue of mice with dietary steatosis after 70% hepatectomy. Increased expression of Cd36/Fat (a) was observed on postoperative days (PHx+) 1 and 2. Fatty acid-binding protein (Fabp-1) expression (b) was elevated on PHx+2 and Fatp-5 expression (c) on PHx+2 and 7. Expression of the crucial regenerative factor hepatocyte growth factor (Hgf) (d) was increased on PHx+1 in standard diet (SD)- and on PHx+1 and 2 in western diet (WD)-fed mice. Expression of the fat-metabolism-related transcription factor Pparα (e) was not changed significantly, Acox1 (f) and Pdk1 (g) (both target genes of Pparα) were elevated on PHx+2 in WD-fed animals. Data represent relative expression vs SD-fed animals (fold change) as mean±s.e.m., *P<0.05 vs SD pre-OP. PHx: 70% hepatectomy.

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