Table 1 Serum-derived parameters and liver triglycerides of animals fed a standard (SD) or western diet (WD) before PHx (pre-OP) or on postoperative days 1, 2 and 7 (PHx +)

From: Steatosis does not impair liver regeneration after partial hepatectomy

Parameter

Time point

SD

WD

P-valuea

FFA (nmol)

Pre-OP

5.3±0.21

9.85±0.14

<0.0001a

 

PHx+1

9.05±0.66

9.26±0.47

n.s.

 

PHx+2

8.19±1.16

8.81±0.65

n.s.

 

PHx+7

8.78±0.64

9.04±0.61

n.s.

Triglycerides (liver tissue) (μmol/mg)

Pre-OP

41.27±5.60

78.98±8.52

0.0008a

 

PHx+1

32.93±7.09

99.27±16.36

0.04a

 

PHx+2

63.17±1.44

113.7±18.26

0.03a

 

PHx+7

25.05±11.85

103.3±19.52

0.03a

AST (IU/l)

Pre-OP

26.75±8.0

46.25±13.7

n.s.

 

PHx+1

4480.0±18

2038.0±169.3

n.s.

 

PHx+2

113.0±10.54

114.7±16.88

n.s.

 

PHx+7

68.33±33.22

72.83±28.78

n.s.

ALT (IU/l)

Pre-OP

17.5±4.91

63.0±29.85

n.s.

 

PHx+1

2269.0±389.1

1099.0±154.4

0.012a

 

PHx+2

99.33±8.69

68.33±9.04

n.s.

 

PHx+7

90.0±56.87

47.17±31.34

n.s.

LDH (IU/l)

Pre-OP

732.5±201.1

2002.0±161.7

n.s.

 

PHx+1

30 610.0±3676.0

18 201.0±2311.0

0.02a

 

PHx+2

2319.0±559.1

1368.0±374.1

n.s.

 

PHx+7

2344.0±832.2

2578.0±345.4

n.s.

T-protein (g/dl)

Pre-OP

4.13±0.08

4.33±0.21

n.s.

 

PHx+1

3.73±0.10

3.67±0.15

n.s.

 

PHx+2

3.03±0.38

1.97±0.18

n.s.

 

PHx+7

3.73±0.18

3.48±1.13

n.s.

Albumin (g/dl)

Pre-OP

2.0±0.06

1.33±0.33

n.s.

 

PHx+1

1.85±0.09

1.92±0.06

n.s.

 

PHx+2

1.25±0.25

1.0±0.04

n.s.

 

PHx+7

2.0±0.06

1.67±0.07

n.s.

Bilirubin (mg/dl)

Pre-OP

0.48±0.08

0.3±0.04

n.s.

 

PHx+1

2.05±0.92

2.17±0.82

n.s.

 

PHx+2

0.3±0.06

0.37±0.08

n.s.

 

PHx+7

0.47±0.07

0.38±0.03

n.s.

Leptin (pg/ml)

Pre-OP

983.4±170.9

36 416.0±21 377.0

n.s.

 

PHx+1

5242.0±1042.0

17 260.0±2431.0

0.01a

 

PHx+2

1087.0±355.7

6717.0±695.4

0.002a

 

PHx+7

975.5±190.1

4650.0±412.6

0.001a

Adiponectin (ng/ml)

Pre-OP

2.72±0.84

2.11±1.19

n.s.

 

PHx+1

4.06±0.51

5.44±0.75

n.s.

 

PHx+2

1.98±0.42

1.96±0.61

n.s.

 

PHx+7

4.27±0.94

3.02±0.68

n.s.

  1. aP-value is given for SD vs WD for each timepoint.
  2. n.s.: not significant.