Figure 3
From: OPA1 downregulation is involved in sorafenib-induced apoptosis in hepatocellular carcinoma
Sorafenib induces mitochondrial fragmentation in hepatocellular carcinoma (HCC) cells. (a) LH86 and (b) Huh7 cells were treated with sorafenib and were stained with mitochondria membrane-dependent MitoTracker®-Red probe. Then, mitochondria morphology was observed under fluorescence microscope (Red) (areas marked with white boxes were enlarged (zoom-in)). (c) LH86 and (d) Huh7 cells were treated with sorafenib (20 μM) for indicated times and the number of cells with fragmented mitochondria was counted (*P<0.05).
