Figure 1 | Laboratory Investigation

Figure 1

From: β1 integrin–extracellular matrix interactions are essential for maintaining exocrine pancreas architecture and function

Figure 1

(a) Representative immunofluorescence images of the pancreas of a transgenic Rosa26loxP-STOP-lacZ mouse crossed with a Col1a2-CRE(ER)T mouse, whereby the β-galactosidase reporter gene is expressed only if cre recombinase is present using anti-glial fibrillary acidic protein (GFAP), anti-β-galactosidase and anti-insulin antibodies (arrows indicate colocalization of GFAP and β-galactosidase, while arrowheads show no colocalization). (b) Relative mRNA expression (normalized to 18S subunit) of collagen type Iα1 (Col1a1), Col1a2, fibronectin 1 (Fn1), laminin α1 (Lama1), laminin β1 (Lamb1) and laminin γ1 (Lamc1) of β1 integrin-deficient and control mouse pancreas at 1 week post-tamoxifen injection (n=3–5). Data are expressed as means±s.e.m. *P<0.05, ***P<0.001 vs controls.

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