Figure 6 | Laboratory Investigation

Figure 6

From: KCa3.1 channels mediate the increase of cell migration and proliferation by advanced glycation endproducts in cultured rat vascular smooth muscle cells

Figure 6

Schematic graph showing the effects of AGEs and insulin on intracellular pathways. AGEs bind to their receptor RAGE and activate P38, ERK1/2, and PI3K/Akt and then promote gene expression of KCa3.1 channels, which has a crucial role in regulating migration and proliferation in VSMCs. Insulin regulates cell proliferation and migration via a similar mechanism.

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