Figure 7
From: Angiostatin production increases in response to decreased nitric oxide in aging rat kidney
Endothelial cell marker expression and inflammatory cytokine in L-NG-nitroarginine methyl ester (L-NAME) or molsidomine-treated aged-rat kidney. (a) Expression of Tie2 as determined by western blot analysis in control (n=4), L-NAME-treated (20 mg/l in drinking water; L-NAME, n=5), and molsidomine-treated (120 mg/l in drinking water; molsidomine, n=6) rats. Values are expressed as mean±s.e.m. *P<0.05 versus control. (b–d) Expression of vascular endothelial growth factor receptor-2 (VEGFR2; a), monocyte chemotactic protein-1 (MCP1; b), and interleukin-18 (IL18; c) mRNA as determined by quantitative real-time PCR. n=4–6 for each group. Values are expressed as mean±s.e.m. *P<0.05 versus control.
