Figure 2 | Laboratory Investigation

Figure 2

From: Blockade of B-cell-activating factor signaling enhances hepatic steatosis induced by a high-fat diet and improves insulin sensitivity

Figure 2

Glucose metabolism and immunological profiles of high-fat diet (HFD)-fed B-cell-activating factor receptor (BAFF-R)−/− mice. (a) Results of a glucose tolerance test and insulin tolerance test for HFD-fed mice after 12 weeks of feeding (n=5 per group). (b) Numbers of B cells in the peripheral blood and serum immunoglobulin G (IgG) levels after 12 weeks of normal diet (ND) or HFD consumption (n=8 per group). (c) Gene expression in epididymal adipose tissues of mice after 12 weeks of ND or HFD consumption. Gene expression data were normalized to those of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and were expressed as a ratio to those obtained for WT mice after 12 weeks of ND feeding (n=8 per group). Error bars in the graphs indicate means±s.e.m. *P<0.05, **P<0.01, and ***P<0.001. TNF, tumor necrosis factor.

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