Figure 3 | Laboratory Investigation

Figure 3

From: Blockade of B-cell-activating factor signaling enhances hepatic steatosis induced by a high-fat diet and improves insulin sensitivity

Figure 3

Liver steatosis in high-fat diet (HFD)-fed B-cell-activating factor receptor (BAFF-R)−/− mice. (a) Serum alanine aminotransferase (ALT) levels of normal diet (ND)- or HFD-fed mice after 12 weeks of feeding (n=8 per group). (b) Hematoxylin and eosin (H&E) staining (left and middle) and Sudan III (right) staining of sections of livers from mice after 12 weeks of HFD consumption; scale bar, 200 μm. (c) Nonalcoholic fatty liver disease (NAFLD) histological activity scores of HFD-fed mice after 12 weeks of feeding (n=8 per group). (d) Hepatic triglyceride and cholesterol levels of mice after 12 weeks of HFD consumption (n=5 per group). Error bars in the graphs indicate means±s.e.m. *P<0.05, **P<0.01, and ***P<0.001.

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