Figure 8 | Laboratory Investigation

Figure 8

From: Cytokines induce tight junction disassembly in airway cells via an EGFR-dependent MAPK/ERK1/2-pathway

Figure 8

Quantitative evaluation of the activity epidermal growth factor receptor (EGFR) and extracellular signal-regulated kinases (ERK)1/2 inhibitors on tight junction (TJ) disassembly induced by exposure to cytokines. The percentage of zonula occludens (ZO)-1/occludin colocalization in Calu-3 cells is expressed on the ordinate and the various culture conditions on the abscissa. Dotted line represents ZO-1/occludin colocalization under basal culture condition (Control). Data reported are representative of the results obtained in four independent experiments and are expressed as mean ± s.e.m.. *P<0.05 and **P<0.01 versus cells exposed to cytokines in cultures without AG1478 or UO126.

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