Figure 1
Expression profiles of Runx family genes. (a) RT-PCR shows that the expression level of RUNX1 and RUNX2 mRNAs are significantly higher in PC tissues than in normal thyroid tissues as shown by the densitometric assessments below (*P<0.05). Although two of four PC cases have a lower expression of RUNX3 mRNA, it is not statistically significant. (b) Immunohistochemistry for Runx2 in thyroid tissues. Follicular cells in normal thyroid (NT) are negative for Runx2. Moderate positivity is observed in adenomatous goiter (AG) and follicular adenoma (FA). A diffuse positivity pattern is exhibited in malignant thyroid tissue including follicular carcinoma (FC), papillary carcinoma (PC) and undifferentiated carcinoma (UC). (c) Immunohistochemistry for Runx1. Follicular cells in NT show moderate positivity for Runx1. Diffuse immunopositivity of Runx1 is observed in PC. (d) Immunohistochemistry for Runx3. Normal follicular cells are moderate positive for Runx3. Tumor cells of PC show mild positivity for Runx3.
