Table 3 Sensitivity of malignant primary bone tumor cell lines to mafosfamide, cisplatin and doxorubicin

From: New chondrosarcoma cell lines and mouse models to study the link between chondrogenesis and chemoresistance

Drugs

Mafosfamide

Cisplatin

Doxorubicin

Tumor type

Cell line

IC50 (μM)

IC50 (μM)

IC50 (nM)

Reference OS

SaOS2

22±3

7±0.9

119±78

 

HOS

7±3

3±0.2

147±37

Reference ES

SKES1

17±7

3±0.6

47±14

 

A673

36±19

3±0.6

150±36

Reference CS

SW1353

20±7

5±0.7

140±44

 

CAL78

46±12

7±3

80±38

 

OUMS27

31±6

6±2

2591±1851

CS cell line

CH03

28±13

5±1

360±55

 

CH56

34±13

9±4

184±54

  1. Results are expressed as mean(IC50)±s.d. N=3–4 independent experiments in triplicate.
Back to article page