Figure 5 | Laboratory Investigation

Figure 5

From: Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis

Figure 5

PAFR engagement increases ECM and adhesion molecules gene machinery. (a) Heat map comparing Control, WT and PAFR KO groups. Red and green colors represent upregulated and downregulated genes, respectively. The color intensity indicates the extent of gene expression. (b) Dot plot representation of upregulated (red dots) and downregulated (green dots) genes comparing UUO-submitted WT animals (group 1) vs control mice. (c) Dot plot representation of upregulated (red dots) and downregulated (green dots) genes comparing UUO-submitted PAFR KO animals (group 2) vs control mice. (d) Volcano graphic representation of upregulated and downregulated genes—red and green dots, respectively—comparing WT (group 1) and PAFR KO mice (group 2) submitted to UUO.

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