Figure 8
Early blockade of PAFR attenuates renal progressive disease. (a) Proteinuria levels were evaluated in animals submitted to UUO and that were treated or not with WEB2170. (b) Levels of urinary NGAL, 7 days after UUO in mice that were treated or not with WEB2170. In (c), we can see representative images of the indicated groups after Picrosirius staining and polarized light evaluation. The quantification of fibrosis deposition can be seen in (d) (*P<0.05 vs Control and **P<0.01 vs Control and UUO+WEB). The gene expression of type I collagen and TGF-β can be observed in (e and f), respectively. *P<0.05 vs UUO.
