Figure 4 | Laboratory Investigation

Figure 4

From: Inhibition of collagen I accumulation reduces glomerulosclerosis by a Hic-5-dependent mechanism in experimental diabetic nephropathy

Figure 4

Diabetic nephropathy-induced α-SMA expression is reduced in NTU281-treated kidneys. STZ-induced diabetes was induced as in Figure 1. Tissue sections were immunostained for α-SMA. (a) Photomicrographs show typical sections for control, diabetic, and NTU281-treated diabetic kidneys at day 240. (b) Quantification of glomerular α-SMA expression. Significant differences are marked as *P<0.01. (c) Glomerular Hic-5 and α-SMA expression were correlated (P<0.001, r2=0.72). Data for animals at day 240 are shown.

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