Figure 6 | Laboratory Investigation

Figure 6

From: Inhibition of collagen I accumulation reduces glomerulosclerosis by a Hic-5-dependent mechanism in experimental diabetic nephropathy

Figure 6

Hic-5 colocalizes with collagen I and α-SMA within segments of affected glomeruli. Although the glomerulosclerosis was in most cases global, occasional examples were seen of glomeruli with segmental lesions. In such examples, Hic-5 was seen to colocalize with collagen I and α-SMA. (a) Glomerulus showing a nonsclerotic, unstained (lower) segment and affected (upper) segment double stained with Hic-5 (VR, red) and α-SMA (DAB, brown). (b) Glomerulus showing a nonsclerotic, unstained (upper) segment and affected (lower) segment double stained with Hic-5 (VR, red) and collagen I (DAB, brown).

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