Figure 5 | Laboratory Investigation

Figure 5

From: Transforming growth factor-α activates pancreatic stellate cells and may be involved in matrix metalloproteinase-1 upregulation

Figure 5

The effects of transforming growth factor (TGF-α) (a) or matrix metalloproteinase-1 (MMP-1) (b) on the migration of RLT-PSC cells and primary pancreatic stellate cells (PSCs), and the effects of TIMP-1 protein (c) and an MMP-1 small interfering RNA (siRNA) (d) on TGF-α-induced RLT-PSC cells migration. The concentrations of TGF-α and MMP-1 were 10 nM and 100 ng/ml, respectively. TIMP-1 concentrations were as indicated. MMP-1 and nonsense (control) siRNAs were used. *P<0.05 and **P<0.01 vs the corresponding controls; ††P<0.01 vs TGF-α only.

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