Figure 6

M2-polarized tumor-associated macrophages (TAMs) increased proteolytic activities of pancreatic cancer cells. Panc-1 and BxPC-3 were indirectly cocultured with M2-polarized TAMs. After 24 h, MMP2 and MMP9 proteolytic activities from pancreatic cancer cells were detected by zymography. CC, coculture; MC, monoculture. The data represent at least three independent experiments.