Figure 2 | Laboratory Investigation

Figure 2

From: Primary esophageal and gastro-esophageal junction cancer xenograft models: clinicopathological features and engraftment

Figure 2

The histology of PTXGs is maintained through serial passaging. (a) A moderately differentiated adenocarcinoma (P0, patient) maintains a similar morphology with identifiable gland formation in the xenografts of (b) passage 1 through to (c) passage 10. (d) A poorly differentiated adenocarcinoma with solid tumor pattern (P0) maintains its morphologic features in (e) passage 1 to (f) passage 4. (g) Moderately/poorly differentiated adenocarcinoma from patient (P0) shows (h) a more moderately differentiated histology in passage 1 and (i) passage 3 but still retains similar features. (j) A well/moderately differentiated squamous cell carcinoma with numerous squamous ‘nests’ (P0) shows similar morphology in (k) passage 1 to (l) passage 3.

Back to article page