Table 3 Significant clinicopathological characteristics of engraftment

From: Primary esophageal and gastro-esophageal junction cancer xenograft models: clinicopathological features and engraftment

Characteristics

Engrafted no. of patients (%)

Non-engrafted no. of patients (%)

Odds ratio (95% CI)

P-value

All subtypes (n=70)

 Neo-adjuvant chemo-rad

Yes

5 (22%)

24 (51%)

0.27

0.02a

No

18 (78%)

23 (49%)

(0.1–0.8)

 

 Site of implantation

Abdomen

7 (30%)

28 (60%)

0.3

0.04

Flank

16 (70%)

19 (40%)

(0.1–0.7)

 

Adenocarcinoma (n=54)

 Differentiationb

Poor

11 (61%)

11 (31%)

3.67

0.04a

Moderate/well

6 (33%)

23 (64%)

(1.1–12.6)

 

 Neo-adjuvant chemo-rad

Yes

4 (22%)

20 (56%)

0.23

0.03

No

14 (78%)

16 (44%)

(0.1–0.8)

 

Squamous cell carcinoma (n=16)

 Mean age (range)

74.3 (61–85)

61.5 (46-73)

1.21 (1.0–1.6)

0.02

 Sex

Male

1 (20%)

10 (91%)

0.03

0.02a

Female

4 (80%)

1 (9%)

(0.001–0.5)

 

 Site of implantation

Abdomen

0

8 (73%)

0.04

0.03

Flank

5 (100%)

3 (27%)

(0.002–0.9)

 
  1. Abbreviation: CI, confidence interval.
  2. Fisher’s exact test was used to compare engrafted and non-engrafted predictors.
  3. Student’s t-test was used for to determine if age was a predictor of engraftment.
  4. aOnly significant variable in multivariate analysis.
  5. bPatients with no available information on differentiation were not included in the calculation.