Figure 1 | Laboratory Investigation

Figure 1

From: Hepatic cytochrome P450 deficiency in mouse models for intrahepatic cholestasis predispose to bile salt-induced cholestasis

Figure 1

Characteristics of Atp8b1G308V/G308V/Hrn mice. Mice were fed semisynthetic control diet for 4 weeks, starting from weaning, followed by 0.03% CA-supplemented diet for 4 weeks. (a) Body weight gain in time (n=3–8), (b) plasma bilirubin (n=4–11), (c) plasma ALT (n=5–13), and (d) plasma alkaline phosphatase (AP) at the start (week 0) and at the end (week 8) of the feeding period. (e) Total plasma bile salt concentration (n=3–7) is plotted. Data are shown as mean±s.e.m. *P<0.05; **P<0.001; ***P<0.0001.

Back to article page