Table 1 Liver weight and liver to body weight ratios in 0.03% cholic acid-fed mice

From: Hepatic cytochrome P450 deficiency in mouse models for intrahepatic cholestasis predispose to bile salt-induced cholestasis

 

WT (n=17)

Hrn (n=10)

Atp8b1G308V/G308V (n=4)

Atp8b1G308V/G308V/Hrn (n=6)

Abcb4−/− (n=8)

Abcb4−/−/Hrn (n=6)

Liver weight

1.39±0.05

1.68±0.06a

2.21±0.12b,c

1.93±0.10b,d

2.08±0.43b,c

2.91±0.35b,e,f

Liver/body weight ratio

5.74±0.11

7.27±0.15a

12.157±0.70b,c

12.89±0.52b,c

7.48±0.39b

10.82±0.61b,c,g

  1. At the end of the bile salt feeding period, mice were killed and liver weight and body weight were determined. Data are given as mean±s.e.m. Significance was tested using Student’s t-test.
  2. aP<0.001 compared with WT.
  3. bP<0.0001 compared with WT.
  4. cP<0.0001 compared with Hrn.
  5. dP<0.05 compared with Hrn.
  6. eP<0.001 compared with Hrn.
  7. fP<0.05 compared with Abcb4 −/−.
  8. P<0.001 compared with Abcb4 −/−.
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