Figure 3 | Laboratory Investigation

Figure 3

From: Downregulation of spleen tyrosine kinase in hepatocellular carcinoma by promoter CpG island hypermethylation and its potential role in carcinogenesis

Figure 3

Gene expression profiling. (a) Volcano plots visualize differential gene expression analysis. Red and green dots indicate SYK-regulated genes (n=47) of which expression was >1.5-fold increased and decreased, respectively, after SYK induction in both Hep3B and Huh7 cells and the difference was statistically significant (P-value <0.05, Student’s t-test). (b) Heat map displays expression changes in a cluster of 47 genes with SYK induction (−, no treatment of Dox; +, treatment of Dox). Green to red indicates down to up regulation after Dox treatment. (c) Top three biological functions of GO term associated with 47 genes regulated by SYK induction.

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