Figure 6
From: Generation of pluripotent stem cells without the use of genetic material
Schematic representation of hiPSC generation from human somatic cells by reducing the number of TFs with and without small molecules. (a) hiPSCs using four TFs (Oct4 [O], Sox2 [S], Klf4 [K], and c-Myc [M]);8 (b) hiPSCs from human neonatal epidermal keratinocytes (HNEKs) using two TFs (O, K);71 (c) hiPSCs from human umbilical vein endothelial cells (HUVECs) using two TFs (O, S);70 (d) hiPSCs from HUVECs using one TF (O);43 (e) hiPSCs from human newborn fibroblasts (HNFs) using no TFs;18 and (f) hiPSCs from human NSCs using no TFs.90 HCM medium indicates EndoGRO-VEGF complete medium (CHEMICON). LS and SF medium indicates low-serum and serum-free media, respectively. O, S, K, and M indicate the TFs Oct4, Sox2, Klf4, and c-Myc, respectively.
